Freeze drying is a popular solution for sample prepping and long term storage. The freeze-drying process functions to preserve a material by rapidly freezing it and then using sublimation to remove the ice. Many corporations use industrial freeze dryers for preservation. If you’re interested in buying an industrial freeze dryer for your corporation, here are a few things you should consider.
How Much Moisture Do You Want to Remove?
One factor that you should consider is how much moisture you want to remove from the materials you’re preserving. For example, if you’re processing 12 liters of total liquid, you will need a unit that is 12 liters or larger. It is recommended that you choose a freezer dryer that has a volume of 50 percent more than the amount of moisture you want to remove. You should also keep in mind that there are some drying chamber accessories that are only compatible with a base unit that is six liters or larger. This true no matter the size of the sample.
What Type of Samples Are You Processing?
Another factor that you should consider is what type of samples you’re processing. You should keep in mind that each component of a sample is important. Therefore, you need to consider all of the solutes and solvents that make up a sample.
The freeze drying process demands a temperature differential of about 20 degrees between the collector chamber and the freezing point of the sample. If the collector is not colder than the material’s freezing point, the sublimated matter may end up entering the freeze dryer’s vacuum pump. The freeze dryer will incur damage if this occurs.
-50°C for the standard system is sufficient to freeze most biological samples. However, some samples like HPLC preparations in acetonitrile have a boiling point of -42°C. For these samples, a much lower temperature is needed for freezing. There are cascade-type collectors out there that are able to reach -84°C, which is sufficient for these samples. If methanol is used for the freeze drying process, a temperature of -105°C may be needed because the freezing point of methanol is -97.6°C.
Acidic samples can cause severe damage to a freeze dryer’s stainless steel coils. Therefore, if your samples are acidic, you should look for a freeze dryer with a PTFE coating to prevent holes in the collector and rust.
As you can see, there are many factors that you should consider when buying an industrial freeze dryer. For more information about freeze dryers and how you can buy one that meets the needs of your company, don’t hesitate to contact us.